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Bruce Conklin and his team at Gladstone are tackling Charcot-Marie-Tooth (CMT) disease, the most common inherited neurological disorders—for which there is currently no cure.
Gladstone Experts Conklin Lab CRISPR/Gene Editing
For National DNA Day, discover how Gladstone scientists are utilizing the power of DNA to deepen our understanding of disease.
Gladstone Experts Genomic Immunology Data Science and Biotechnology Marson Lab Pollard Lab Ramani Lab Shipman Lab Tcheandjieu Lab Big Data CRISPR/Gene Editing
Nature—Bacteria are under constant attack from viruses called bacteriophages, and have evolved complex methods to fight off those invaders. Gladstone Investigator Seth Shipman describes how his group is capitalizing on one of those bacterial defense systems—retrons—to create new molecular biology tools.
Gladstone Experts Data Science and Biotechnology Shipman Lab CRISPR/Gene Editing
The San Francisco Experience—In a podcast interview, Gladstone President Deepak Srivastava discusses the mission of Gladstone Institutes, and describes how advances in stem cell biology, genome engineering, and artificial intelligence are making it possible to understand the core of diseases and develop new cures.
Gladstone Experts Srivastava Lab AI CRISPR/Gene Editing Stem Cells/iPSCs
The Medicine Maker—In this Q&A, the head of the California Institute for Regenerative Medicine highlights the game-changing scientific contributions of Gladstone’s Shinya Yamanaka and Jennifer Doudna.
Gladstone Experts CRISPR/Gene Editing Stem Cells/iPSCs
Scientists at Gladstone and UCSF discover how one protein controls the behavior of immune cells, with potential applications for treating cancer and autoimmune conditions.
News Release Research (Publication) Autoimmune Diseases Cancer Genomic Immunology Krogan Lab Marson Lab CRISPR/Gene Editing
Drug Discovery World—Alex Marson, director of the Gladstone-UCSF Institute of Genomic Immunology, is featured for his innovative work using CRISPR genome editing to develop better cellular therapies for cancer, silencing genes that cause immune cells to become exhausted and activating genes that help them be more effective.
Gladstone Experts Cancer Genomic Immunology Marson Lab CRISPR/Gene Editing
Scientists at Gladstone Institutes develop a streamlined and rapid way to engineer bacteria-fighting viruses known as phages
News Release Research (Publication) Data Science and Biotechnology Shipman Lab CRISPR/Gene Editing
Scientists uncover an ancient immune-evading strategy shared by animal viruses and viruses that infect bacteria; findings may help in the development of new antiviral therapies
News Release Research (Publication) Data Science and Biotechnology Virology Doudna Lab CRISPR/Gene Editing
Scientists at Gladstone develop a more efficient way to make several, precise edits simultaneously to human cells
News Release Research (Publication) Data Science and Biotechnology Shipman Lab CRISPR/Gene Editing
The Voice of San Francisco—Gladstone President Deepak Srivastava, MD, talks about technologies driving the next wave of medicine, the importance of philanthropy dollars in fueling scientific breakthroughs, and how biotech is still breathing life into San Francisco's Mission Bay neighborhood.
Philanthropy Srivastava Lab Aging AI CRISPR/Gene Editing Stem Cells/iPSCs
A new study in Nature Genetics expands our understanding of immune regulation and autoimmunity—with findings that could also be used in the development of cancer immunotherapies.
News Release Autoimmune Diseases Cancer Genomic Immunology Parker Institute for Cancer Immunotherapy Marson Lab Pollard Lab Ye Lab AI CRISPR/Gene Editing
Funds from the California Institute for Regenerative Medicine will allow Gladstone to bolster its disease-modeling technologies, add robust CRISPR screening capabilities, and educate young researchers on the latest in stem cell science.
Grants Assay Development and Drug Discovery Core Bioinformatics Core Stem Cell Core CRISPR/Gene Editing Disease Models Organoids Regenerative Medicine Stem Cells/iPSCs
The health and science publication STAT has selected a breakthrough discovery from Gladstone to be part of its annual STAT Madness competition, in which research institutes compete for the title of champion. The winner is deemed the most innovative research institution in the country.
Research (Publication) Cancer Genomic Immunology Doudna Lab CRISPR/Gene Editing
BioTechniques—Researchers at Gladstone Institutes have mapped the human immune response using next-generation CRISPR technology known as base editing. Using this tool, the team was able to identify specific nucleotides within T cells that influence immune cells’ response to stimuli, creating maps of DNA sequences and protein sites that are involved in human immune responses. The discoveries this project has facilitated could improve existing immunotherapies and reveal new drug targets for autoimmune diseases and cancer.
Research (Publication) Autoimmune Diseases Cancer Genomic Immunology Doudna Lab Marson Lab CRISPR/Gene Editing Genomics
